Basic Information
VIS ID
TVIS30016475
Fusion event
HIV-PCMT1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
150093287/149772151 (Hg38)
End
150093390/149772151 (Hg38)
Orient
+
Location type
Intronic
Target gene
PCMT1
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-877-3p ; hsa-mir-106b-3p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-330-3p ; hsa-mir-508-3p ; hsa-mir-570-5p ; hsa-mir-646 ; hsa-mir-3135a ; hsa-mir-548ag ; hsa-mir-548ai ; hsa-mir-4477b ; hsa-mir-7856-5p ; hsa-mir-548ba ; hsa-mir-4445-5p ; hsa-mir-1283 ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-219a-5p ; hsa-mir-6766-3p ; hsa-mir-4782-3p
Nearest miRNA
hsa-mir-10398/Upstream/9088268; hsa-mir-1202/Downstream/1330524;
Nearest TSS
ENST00000381078/Upstream/22107; ENST00000480010/Downstream/26021;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/22002, chr6-CpG: 167/Downstream/91057
Upstream sequence
TGCTGAACTGCTGAGCCTTGGCAGTGGGCGCCTTTGAGGCTTAGAAGTGCCTCAGGATTCTGTCAGTCGGCTGCCATGCTATCTTCTTTTGACGCACTAT
Downstream sequence
AGTTTTGAGAAAGCAACACCACAAGAAAAGAAACTAAAAGTTAAGAACCACGAAAAGATTGTGTGAATTAACATTAGATGATAAGATAAAGAATAAAATG
Target sequence
AACAGTCAGCAGAGAAGATCCTGGGGAGCTTCTGAACCCCGAAGGCACCTGCTACCACCGCTCAGTGAAACTTGCTTCAGAGGCAGAAAGAAGCAGGTAAATA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate