Basic Information
VIS ID
TVIS30016483
Fusion event
HIV-CHST12 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
2454313/2414678 (Hg38)
End
2454462/2414678 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
CHST12
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-4728-5p ; hsa-mir-1228-5p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-6766-5p ; hsa-mir-6756-5p ; hsa-mir-3175 ; hsa-mir-6731-5p ; hsa-mir-8085 ; hsa-mir-25-5p ; hsa-mir-3656 ; hsa-mir-4767 ; hsa-mir-658 ; hsa-mir-5189-3p ; hsa-mir-1976 ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-4722-3p ; hsa-mir-6777-3p ; hsa-mir-483-3p ; hsa-mir-6715a-3p ; hsa-mir-497-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p
Nearest miRNA
hsa-mir-339/Upstream/157101; hsa-mir-10399/Downstream/112396;
Nearest TSS
ENST00000635602/Upstream/10579; ENST00000313156/Downstream/23085;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/10302, chr7-CpG: 130/Downstream/17932
Upstream sequence
ccagcctttactttctttaatggtaaaatttgagaatcctaagttttaaattttgataaagtccaatttaccacatttttctctcatatttgtgcttttg
Downstream sequence
tcatgcagatatccagttgtttcagcaccatttgttgaaaagattgttattccttattgaattactttgccaccttttgaaaacagccacatacatgtgg
Target sequence
gtatcccaacaaatctttgccttctcccaagtcatggagattttttcctgttttcctctgaatattttagttttagtgtttatgtgtaaggccatgatccattgtgagttaatttctgtgtgaggcgtagggttgaggttcattctttt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate