Basic Information
VIS ID
TVIS30016486
Fusion event
HIV-MIOS integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
7635692/7596061 (Hg38)
End
7635841/7596061 (Hg38)
Orient
+
Location type
Intronic
Target gene
MIOS
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-339/Upstream/529016; hsa-mir-10399/Downstream/10531159;
Nearest TSS
ENST00000635602/Upstream/13107; ENST00000479694/Downstream/9057;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/28669, chr7-CpG: 69/Downstream/44148
Upstream sequence
CAGTGTGAATTCTGAAGTCATTGTTATTTCTAAAATGTTGGAGTCTAAAGTTTGAGTTCTTCCACCAATTTCAGTGGTATTAGTAAGAATATAATTAAAA
Downstream sequence
ATTATGGTTTGCATTACATTTATTTTTTCTTTCATTTGTTTTGTAGGTTTTTGTGAGTTGCAATTTCTGTGGCAAGTCAATCTCCTACAGCTGTTCAGCT
Target sequence
AGGAAGTACCCCAAAAATGTAATTGCTAGGTATAAATTTTAAATGAAAGCTAGTCAACCTTAGCAGATCAATTTTGaaatataaaataaagttttttaaaagtatttaaaaataatttGTTAGGCGCACACTAAGTTATTTAGCATTCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate