Basic Information
VIS ID
TVIS30016492
Fusion event
HIV-ETV1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
13960839/13921214 (Hg38)
End
13960761/13921214 (Hg38)
Orient
-
Location type
Intronic
Target gene
ETV1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-339/Upstream/6854169; hsa-mir-10399/Downstream/4206006;
Nearest TSS
ENST00000635602/Upstream/14716; ENST00000412014/Downstream/64275;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1233591, chr7-CpG: 18/Downstream/68539
Nearest cancer related gene
ETV1(OG, No orient, 0)
Upstream sequence
CTTGAATTTCTTTAAGCAATAGTTTTAGAGTTAGGAGGGAAAAAATGAGCTGCCATGTTTCAGGAGAAAATGTAGCCATAAGCAAGTGATGTTTTGTAAT
Downstream sequence
GGAATAAGGCCACGGTTTAGCCTTTGGAAGTGTTACATATCAAGCACAAAAGGCCAAAGTTCATGGAATCATAATCATTGCTGCCCTGGAAATTACTAAA
Target sequence
TTTTAGAGTTAGGAGGGAAAAAATGAGCTGCCATGTTTCAGGAGAAAATGTAGCCATAAGCAAGTGATGTTTTGTAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate