Basic Information
VIS ID
TVIS30016496
Fusion event
HIV-OSBPL3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
24858410/24818791 (Hg38)
End
24858612/24818791 (Hg38)
Orient
+
Location type
Intronic
Target gene
OSBPL3
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-4762-3p ; hsa-mir-3192-3p ; hsa-mir-4662a-5p ; hsa-mir-3151-3p ; hsa-mir-6890-3p ; hsa-mir-3163 ; hsa-mir-449b-3p ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-6499-3p ; hsa-mir-539-5p ; hsa-mir-6838-5p ; hsa-mir-4519 ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-548e-5p ; hsa-mir-4712-3p ; hsa-mir-4757-3p ; hsa-mir-4517 ; hsa-mir-181d-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-1183/Upstream/3347645; hsa-mir-10399/Downstream/1131128;
Nearest TSS
ENST00000635602/Upstream/3698; ENST00000607375/Downstream/30545;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/60923, chr7-CpG: 134/Downstream/160589
Upstream sequence
aacatcatgagggcagatttaagcccagctacatctacaatcacaacaaacggaaatggtttacacaacctacataaaaggcagagaaatgtcaggctgg
Downstream sequence
cctgtaatcccagcattttgggaggccgaggcaggcggatcacaaggtcaagagatcaagaccatcctggccaacatggtgaaaccccatctctactaaa
Target sequence
gttacaaagcaagattTGGGAATCCTAGGCCCATGGAAATAGGTAGATTGCTCAGGAAAAGGCTGATGGGGAAGTATGGCCTAGGAGAAGGATGCTAAGGCTGAGAAGGGAAGGATGTAACACAGGAGCACACAAAACTACTTTGAGAAGACCCCTCGCATTAAAAAAAAATCCAACTTTTggctgggcgcagtggctcatg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate