Basic Information
VIS ID
TVIS30016504
Fusion event
HIV-NT5C3A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
33074794/33035182 (Hg38)
End
33074681/33035182 (Hg38)
Orient
-
Location type
Intronic
Target gene
NT5C3A
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-122-5p ; hsa-mir-16-5p ; hsa-mir-320a ; hsa-mir-582-5p ; hsa-mir-101-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-6504-3p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-144-3p
Nearest miRNA
hsa-mir-1183/Upstream/302105; hsa-mir-10399/Downstream/1905578;
Nearest TSS
ENST00000635602/Upstream/8149; ENST00000482941/Downstream/801;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/77203, chr7-CpG: 80/Downstream/27144
Upstream sequence
TTTTCACTGAGTATGAATAATAACACATAGTTGGCGGTTTCACACCCATTTCTTAAAGGTAAGATTACTGCTCTCATTCAGGGCTATAGAAGCTAATAAG
Downstream sequence
GAATGAGttttttttttttttttttttttgagacggaatctcgctctgtcgcccaggctggagtgcagtggcgcaatcttggctcactgcaaccttcgcc
Target sequence
TAGGAACTTGACGTTTTCACTGAGTATGAATAATAACACATAGTTGGCGGTTTCACACCCATTTCTTAAAGGTAAGATTACTGCTCTCATTCAGGGCTATAGAAGCTAATAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate