Basic Information
VIS ID
TVIS30016510
Fusion event
HIV-OGDH integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
44661917/44622318 (Hg38)
End
44661766/44622318 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7D
Target gene
OGDH
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-361-5p ; hsa-mir-552-5p ; hsa-mir-4326 ; hsa-mir-1293 ; hsa-mir-1321 ; hsa-mir-149-3p ; hsa-mir-151a-5p ; hsa-mir-151b ; hsa-mir-1914-3p ; hsa-mir-2278 ; hsa-mir-2467-3p ; hsa-mir-3141 ; hsa-mir-4419a ; hsa-mir-4468 ; hsa-mir-4483 ; hsa-mir-4510 ; hsa-mir-4651 ; hsa-mir-4728-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4779 ; hsa-mir-5194 ; hsa-mir-608 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6738-5p ; hsa-mir-6782-5p ; hsa-mir-6785-5p ; hsa-mir-6873-5p ; hsa-mir-6883-5p ; hsa-mir-891a-3p ; hsa-mir-4712-3p
Nearest miRNA
hsa-mir-1183/Upstream/511406; hsa-mir-10399/Downstream/259430;
Nearest TSS
ENST00000635602/Upstream/15679; ENST00000497326/Downstream/44303;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/15094, chr7-CpG: 131/Downstream/126106
Upstream sequence
ATAGCATAAAATGAAGCAACAGTAGTATTTTTGCTGTCAATGTTAGGGCTGTTTGTCTTCCTTAAATATATCAGTGGAAAAACTTGGAGTGTAGTTGGAG
Downstream sequence
GTAGGAAGAACTACCGAATTAACTTAAAACTTTTGATTTCTAAAGTGAAAACCCAGGGGTAAAGATTGCATTCCCTAATTATATCCAGAATATATTGCTT
Target sequence
TAAAGGAAAAAAATGAACATTTTCCTTTGAGCCTGAGAAATTAAAAAAAAAATAGCATAAAATGAAGCAACAGTAGTATTTTTGCTGTCAATGTTAGGGCTGTTTGTCTTCCTTAAATATATCAGTGGAAAAACTTGGAGTGTAGTTGGAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate