Basic Information
VIS ID
TVIS30016513
Fusion event
HIV-H2AFV integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
44868581/44828982 (Hg38)
End
44868539/44828982 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA7D
Target gene
H2AFV
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-484 ; hsa-mir-100-5p ; hsa-mir-17-3p ; hsa-mir-136-5p ; hsa-mir-299-5p
Nearest miRNA
hsa-mir-1183/Upstream/718070; hsa-mir-10399/Downstream/52766;
Nearest TSS
ENST00000635602/Upstream/30168; ENST00000450016/Downstream/19039;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/31783, chr7-CpG: 72/Downstream/18686
Upstream sequence
tcttgatttccacatggcccctctatcttcaagtcagcaatagcaccttgggccttcctttgaatctgactcctgcatcctcttccatttttaagggttc
Downstream sequence
atgtaattacactgggttcccccaggtaatccaggataatatctctattttagaaattttagttacatctgcaaagtcccttttaccacataatgtaaca
Target sequence
tttgaatctgactcctgcatcctcttccatttttaagggttc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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