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TVIS30016526
Basic Information
VIS ID
TVIS30016526
Fusion event
HIV-CDK6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
92382430/92753116 (Hg38)
End
92382263/92753116 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7E
Target gene
CDK6
miRNAs that regulate target gene
hsa-mir-195-5p
;
hsa-let-7a-5p
;
hsa-mir-29a-3p
;
hsa-mir-29b-3p
;
hsa-mir-34b-5p
;
hsa-mir-424-5p
;
hsa-mir-16-5p
;
hsa-mir-34a-5p
;
hsa-mir-107
;
hsa-mir-30a-3p
;
hsa-let-7b-5p
;
hsa-mir-21-5p
;
hsa-mir-137
;
hsa-mir-124-3p
;
hsa-mir-449a
;
hsa-mir-29c-3p
;
hsa-mir-34b-3p
;
hsa-mir-34c-5p
;
hsa-mir-185-5p
;
hsa-mir-203a-3p
;
hsa-mir-494-3p
;
hsa-mir-26a-5p
;
hsa-mir-26b-5p
;
hsa-mir-191-5p
;
hsa-mir-218-5p
;
hsa-mir-449b-5p
;
hsa-mir-193b-3p
;
hsa-mir-103a-3p
;
hsa-mir-22-3p
;
hsa-mir-1303
;
hsa-mir-615-3p
;
hsa-mir-512-5p
;
hsa-mir-452-5p
;
hsa-mir-378a-3p
;
hsa-mir-129-5p
;
hsa-mir-129-2-3p
;
hsa-mir-145-5p
;
hsa-mir-506-3p
;
hsa-mir-513a-3p
;
hsa-mir-670-3p
;
hsa-mir-513c-3p
;
hsa-mir-3606-3p
;
hsa-mir-6757-3p
;
hsa-mir-561-5p
;
hsa-mir-4761-5p
;
hsa-mir-6801-5p
;
hsa-mir-3941
;
hsa-mir-8485
;
hsa-mir-147a
;
hsa-mir-1298-5p
;
hsa-mir-551b-5p
;
hsa-mir-140-3p
;
hsa-mir-384
;
hsa-mir-5682
;
hsa-mir-216b-5p
;
hsa-mir-548v
;
hsa-mir-1179
;
hsa-mir-4310
;
hsa-mir-4291
;
hsa-mir-7157-5p
;
hsa-mir-1236-3p
;
hsa-mir-214-3p
;
hsa-mir-761
;
hsa-mir-922
;
hsa-mir-3619-5p
;
hsa-mir-6809-3p
;
hsa-mir-373-5p
;
hsa-mir-616-5p
;
hsa-mir-371b-5p
;
hsa-mir-371a-5p
;
hsa-mir-372-5p
;
hsa-mir-3671
;
hsa-mir-504-5p
;
hsa-mir-200a-3p
;
hsa-mir-105-5p
;
hsa-mir-205-5p
;
hsa-mir-4256
;
hsa-mir-6836-5p
;
hsa-mir-6821-3p
;
hsa-mir-6132
;
hsa-mir-6790-3p
;
hsa-mir-4750-3p
;
hsa-mir-301b-5p
;
hsa-mir-301a-5p
;
hsa-mir-4714-5p
;
hsa-mir-15b-5p
;
hsa-mir-497-5p
;
hsa-mir-6838-5p
;
hsa-mir-15a-5p
;
hsa-mir-498
;
hsa-mir-2054
;
hsa-mir-3915
;
hsa-mir-644a
;
hsa-mir-3911
;
hsa-mir-891a-3p
;
hsa-mir-3688-5p
;
hsa-mir-3928-3p
;
hsa-mir-3922-5p
;
hsa-mir-4717-5p
;
hsa-mir-449c-5p
;
hsa-mir-2682-5p
;
hsa-mir-4753-5p
;
hsa-mir-8054
;
hsa-mir-548k
;
hsa-mir-548av-5p
;
hsa-mir-5587-5p
;
hsa-mir-7853-5p
;
hsa-mir-7849-3p
;
hsa-mir-5197-5p
;
hsa-mir-302c-5p
;
hsa-mir-302d-5p
;
hsa-mir-302b-5p
;
hsa-mir-7152-5p
;
hsa-mir-183-3p
;
hsa-mir-4326
;
hsa-mir-4680-3p
;
hsa-mir-1266-3p
;
hsa-mir-4724-5p
;
hsa-mir-548c-3p
;
hsa-mir-4753-3p
;
hsa-mir-885-3p
;
hsa-mir-942-5p
;
hsa-mir-6868-5p
;
hsa-mir-6515-3p
;
hsa-mir-222-3p
;
hsa-mir-221-3p
;
hsa-mir-187-5p
;
hsa-mir-6782-3p
;
hsa-mir-491-3p
;
hsa-mir-3613-5p
;
hsa-mir-219a-2-3p
;
hsa-mir-5739
;
hsa-mir-5091
;
hsa-mir-6716-3p
;
hsa-mir-502-3p
;
hsa-mir-501-3p
;
hsa-mir-646
;
hsa-mir-8064
;
hsa-mir-4643
;
hsa-mir-603
;
hsa-mir-362-3p
;
hsa-mir-329-3p
;
hsa-mir-888-5p
;
hsa-mir-302f
;
hsa-mir-342-3p
;
hsa-mir-3685
;
hsa-mir-607
;
hsa-mir-155-3p
;
hsa-mir-548n
;
hsa-mir-1972
;
hsa-mir-624-5p
;
hsa-mir-500b-3p
;
hsa-mir-3159
;
hsa-mir-6871-3p
;
hsa-mir-4482-5p
;
hsa-mir-3130-5p
;
hsa-mir-541-5p
;
hsa-mir-5195-3p
;
hsa-mir-340-5p
;
hsa-mir-491-5p
;
hsa-mir-20b-5p
;
hsa-mir-34a-3p
;
hsa-mir-195-3p
;
hsa-mir-214-5p
;
hsa-mir-1-5p
;
hsa-mir-203a-5p
;
hsa-mir-211-5p
;
hsa-mir-320a
;
hsa-mir-892b
;
hsa-mir-3138
;
hsa-mir-3663-3p
;
hsa-mir-4426
;
hsa-mir-4491
;
hsa-mir-4534
;
hsa-mir-4647
;
hsa-mir-4657
;
hsa-mir-4662b
;
hsa-mir-6894-5p
;
hsa-mir-7154-3p
;
hsa-mir-765
;
hsa-mir-766-5p
;
hsa-mir-767-5p
;
hsa-mir-7847-3p
;
hsa-mir-8082
;
hsa-mir-4693-3p
;
hsa-mir-621
;
hsa-mir-6761-5p
;
hsa-mir-7855-5p
Nearest miRNA
hsa-mir-10525/Upstream/549018; hsa-mir-10399/Downstream/729644;
Nearest TSS
ENST00000635602/Upstream/27406;
ENST00000452050/Downstream/80801;
Nearest CpG islands
None/Target,
chr7-CpG: 39/Upstream/162557
,
chr7-CpG: 316/Downstream/79771
Nearest cancer related gene
CDK6
(TSG, No orient, 0)
Upstream sequence
ATATTTTCATATTTAACCAAAGAAACAACCTACTTTATGGTGATTAAATCTACTTCTGAACATCAAATTGTGACCTTATTAAGTTATTAAATTATATGCT
Downstream sequence
TCACCTGTGAATACTGAAGCATATGATTTAATAACTTAATAAATGTCACAACCTGATGTTCAGAAGTGGATTTAATCTCAAATAGAATTCAATTACTGAT
Target sequence
AAAGAAACAATTCTGAAATAATAATGCTTTTTAAACATGAAGCAAGCCTAATTTATTTACTTTCTCTATATTTTCATATTTAACCAAAGAAACAACCTACTTTATGGTGATTAAATCTACTTCTGAACATCAAATTGTGACCTTATTAAGTTATTAAATTATATGCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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