Basic Information
VIS ID
TVIS30016529
Fusion event
HIV-TRRAP integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
98504670/98907047 (Hg38)
End
98504573/98907047 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
TRRAP
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-9-5p ; hsa-mir-30a-5p ; hsa-mir-1301-3p ; hsa-mir-1229-3p ; hsa-mir-760 ; hsa-mir-193b-3p ; hsa-mir-330-3p ; hsa-mir-106b-5p ; hsa-mir-185-5p ; hsa-mir-181b-5p ; hsa-mir-31-5p ; hsa-mir-23a-3p ; hsa-mir-17-5p ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-10525/Upstream/25318; hsa-mir-10399/Downstream/502125;
Nearest TSS
ENST00000635602/Upstream/6367; ENST00000480695/Downstream/63140;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/27716, chr7-CpG: 20/Downstream/46130
Upstream sequence
CTGCACAGGGAGATGGAGTAATGTTGCTAATATCTTAATGTATGTCCGTATAATCTTTGTTTCTTACACTTAAAAAAAAAAAAAAAGTAGTTGTggccag
Downstream sequence
gcacggtggctcacgcctgtaatcccagcactttgggaggccgaggcgggcagatcacctgaggtcgggagtttgagaccagcctgaccaacatgaagaa
Target sequence
CACAGGGAGATGGAGTAATGTTGCTAATATCTTAATGTATGTCCGTATAATCTTTGTTTCTTACACTTAAAAAAAAAAAAAAAGTAGTTGTggccag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate