Basic Information
VIS ID
TVIS30016530
Fusion event
HIV-ARPC1A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
98946277/99348654 (Hg38)
End
98946365/99348654 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
ARPC1A
miRNAs that regulate target gene
hsa-mir-1274a ; hsa-mir-423-5p ; hsa-let-7i-5p
Nearest miRNA
hsa-mir-10525/Upstream/466925; hsa-mir-10399/Downstream/60518;
Nearest TSS
ENST00000635602/Upstream/22727; ENST00000471960/Downstream/5281;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/22302, chr7-CpG: 145/Downstream/25372
Upstream sequence
aaattagccagTCTCAGATCATAACCTGGTATCAAAAAACCTTGTCTCTGGCAGAAGGCCTGGTGACCGACAGAAGAACGTTGAATGCTCTGTTACTTTT
Downstream sequence
attaaGGAAAAGTGTGGCCTACTTAGGTATTTTCACCTGACATACATTTGTAGGTCATTTGGGGATGCTGGTTGAGTGGATAAACTGAAACAGTTTTCCC
Target sequence
CTATAGAATCTTTTTTTATAGAAACCTATCTGAAAAAGTTTATTCTGaaaaaaataatattctgaattgttttataatttttttttaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate