Basic Information
VIS ID
TVIS30016532
Fusion event
HIV-ZNF655 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99161199/99563576 (Hg38)
End
99161313/99563576 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
ZNF655
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-423-5p ; hsa-mir-129-5p ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-584-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-5698 ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-4284 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-6890-3p ; hsa-mir-6778-3p
Nearest miRNA
hsa-mir-10525/Upstream/154312; hsa-mir-10399/Downstream/529984;
Nearest TSS
ENST00000635602/Upstream/4714; ENST00000494357/Downstream/6623;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/4230, chr7-CpG: 29/Downstream/16615
Upstream sequence
cccgcctaattttgtatttttagtagagacggggtttcaccatgctggtcaggctgatctcgaactcttgacctcaagtgatccaccttccttggcctcc
Downstream sequence
CTTTTCTTTTTTTTTTTTCCGTTGGCTTTGTCTATGCTGGTGGCATCCAGGGCATTGCTTTGTCTCCCTGATTATGCTCAGGATTCAAGGTCTTCTTATT
Target sequence
caaagtgctggaattacaggcatgagccaccgcacccagccTCCTTTTTCTTTAGTTTCTTGCTTGCTTCTGCACTCTTCTTTTTGTGTGTGTAAATACTGAATCATGCATTTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate