Basic Information
VIS ID
TVIS30016535
Fusion event
HIV-LAMTOR4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99748035/100150412 (Hg38)
End
99748205/100150412 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
LAMTOR4
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-766-3p ; hsa-mir-424-5p ; hsa-mir-331-3p
Nearest miRNA
hsa-mir-10525/Upstream/56338; hsa-mir-10399/Downstream/6193;
Nearest TSS
ENST00000635602/Upstream/1053; ENST00000488338/Downstream/2268;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1392, chr7-CpG: 81/Downstream/7781
Upstream sequence
TTGAGGGAATCCAGGATATTAAAAATTCAACATGTTATGACAAGGTAACTAACTTTCCGGGAGGTAGGAATTCAGCCCACCTTAAAGGAGAGTATTTACA
Downstream sequence
AAGGTAATACAGTTTGAAAGGTTTTTTAAAACAGAAACAAGACCCAGTGAGGTGGTTGAGCAATATTGTTGTTAGTGATGTGAAGATGGGCAGAAGGAGG
Target sequence
GTGGGGGAGGACTTATTTGCAGGTGTGTGGCACTAACCTATCTGAACTGATGGTAAGTTTATGCTGAAAAGATTTGGGAAGGTTTGAGGGAAGAGAGGAGGATATGGTCAGGGAGGATGTAATTGTGAAGGATCTTCAAGGCCAGGTTAACACACTTGAACTTATTCTTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate