Basic Information
VIS ID
TVIS30016537
Fusion event
HIV-SPDYE3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99918523/100320900 (Hg38)
End
99918475/100320900 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA7F
Target gene
SPDYE3
Nearest miRNA
hsa-mir-10525/Upstream/164231; hsa-mir-10399/Downstream/35751;
Nearest TSS
ENST00000635602/Upstream/6459; ENST00000493091/Downstream/31276;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/48438, chr7-CpG: 84/Downstream/14715
Upstream sequence
ACTCTAGCTAGACTTGACATGGGACGTGAATAACCTTCCTGTCTAGAGAGCTGTCTCCTTGAGGTGTGACATTGTCTCTCTCACTTCCAGAACACCGGAC
Downstream sequence
CCAGGGGAGATGTGGATTTTCAGCAGGAACTTTATTCCAGTGCTAATGGCAGACATCAGGAAGGAGGAGAGGAGCCATTTGTGCAGATCATCTAGAAGAA
Target sequence
GTCTCCTTGAGGTGTGACATTGTCTCTCTCACTTCCAGAACACCGGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate