Basic Information
VIS ID
TVIS30016538
Fusion event
HIV-PILRA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99977926/100380303 (Hg38)
End
99977713/100380303 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
PILRA
Nearest miRNA
hsa-mir-10525/Upstream/23582; hsa-mir-10399/Downstream/487733;
Nearest TSS
ENST00000635602/Upstream/6259; ENST00000479201/Downstream/21740;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/43839, chr7-CpG: 199/Downstream/47878
Upstream sequence
GACTATATCTTGGCCTCATCTGTGTTTGGGAAGCCTAAGGCTAGAGTCCCTATATGATTAAAtgaaacaaacttctcccatgaaacgcaaagaacaaaac
Downstream sequence
aaacaggaaaaacagaaagaggaacctggaagaaaccaaaacagttcagggagaataaaactttaaaatactcagcatttccttctactcagaaagctaa
Target sequence
gagaggtttgctttccagaatagatgaaccagagggcctctgggggagcaccccagggataactgGCAAGGCGACTGGGGTCTGGTCCTCATACCGAATCCCCCAGCACCGGGGACTATATCTTGGCCTCATCTGTGTTTGGGAAGCCTAAGGCTAGAGTCCCTATATGATTAAAtgaaacaaacttctcccatgaaacgcaaagaacaaaac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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