Basic Information
VIS ID
TVIS30016540
Fusion event
HIV-KMT2E integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
104723884/105083437 (Hg38)
End
104723999/105083437 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
KMT2E
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1301-3p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-10525/Upstream/2611906; hsa-mir-10399/Downstream/9569908;
Nearest TSS
ENST00000635602/Upstream/6321; ENST00000479838/Downstream/18034;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/68918, chr7-CpG: 28/Downstream/161165
Upstream sequence
ggctgaattagagacactttgatgccctcagtgttgaactcatagggttctgggtggccaggggcattgcccagtatcaaaagacatttaaaaggcaatc
Downstream sequence
tttgttttcccttcaaggcttgggtttagcagctttatagataagggcagtcctgatcataaacccaaatgcatttgcacaaaacagtagagttaatctg
Target sequence
ccttcctagctacctgttgtctgacttgagggacaaagcatcaatggtaccaatccagaaaaagggttctcctccaggttttcttgttatacaaccaaaagactggcagcttccg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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