Basic Information
VIS ID
TVIS30016544
Fusion event
HIV-SRPK2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
104875224/105234777 (Hg38)
End
104875267/105234777 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
SRPK2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-181a-5p ; hsa-mir-21-5p ; hsa-mir-511-5p ; hsa-mir-7977 ; hsa-mir-6740-3p ; hsa-mir-6849-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-4282 ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-10525/Upstream/2763246; hsa-mir-10399/Downstream/9418568;
Nearest TSS
ENST00000635602/Upstream/31045; ENST00000476569/Downstream/34238;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/220258, chr7-CpG: 28/Downstream/9825
Upstream sequence
GTTGGAGAGGCAGCCTTAAAATAACTTACACATTAGAAGAAGAAAAGCAGCAAGCAGAAAAGCACCAAAGCAATGAAGATAGGTGTGCTGATATAAGATT
Downstream sequence
GGTAAGAAAAGAGGGCATCACAGACATGGAGAAGATGGTAACAGAATTTCAAAGAACACATGAATTCCACAAGAAGAAAGAGGTGTTAGACcaagcctgt
Target sequence
CACCACATGCTATATGAAGCAGGAAAAAAAAAGGTTCAGTGTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate