Basic Information
VIS ID
TVIS30016547
Fusion event
HIV-COG5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
107182849/107542404 (Hg38)
End
107183003/107542404 (Hg38)
Orient
+
Location type
Intronic
Target gene
COG5
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-320a ; hsa-mir-3978 ; hsa-mir-4261 ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-610 ; hsa-mir-181a-2-3p ; hsa-mir-497-3p
Nearest miRNA
hsa-mir-10525/Upstream/5070873; hsa-mir-10399/Downstream/7110941;
Nearest TSS
ENST00000635602/Upstream/61462; ENST00000467916/Downstream/5928;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/372520, chr7-CpG: 59/Downstream/21265
Upstream sequence
aaaaacaaaaccacaacaagataccaccacacacctaaaatattagcaaaaactaacaagtttgacaacactaagtgttgacaaggatacaaactaaaag
Downstream sequence
atttgtaaaaaagttttcacagccatattactcataatggtcccaatctggaaacaatccaaattccataagcagaatattcatataatgacatattcta
Target sequence
gaactctcatatactgatagcatatgtggtataaccatttggtaaaatagtttggcattatctaataaagttgaaaatcagaaaccctataacccagaaatctcactcccaggatataacttacacaaaggggtattagcatgagccaacatat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate