Basic Information
VIS ID
TVIS30016566
Fusion event
HIV-BRAF integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
140465262/140765462 (Hg38)
End
140465234/140765462 (Hg38)
Orient
-
Location type
Intronic
Target gene
BRAF
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-378a-5p ; hsa-mir-191-5p ; hsa-mir-143-3p ; hsa-mir-145-5p ; hsa-mir-579-3p
Nearest miRNA
hsa-mir-10399/Upstream/1721305; hsa-mir-11400/Downstream/1709065;
Nearest TSS
ENST00000635602/Upstream/23745; ENST00000563442/Downstream/16215;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/67978, chr7-CpG: 90/Downstream/158735
Nearest cancer related gene
BRAF(OG, No orient, 0)
Upstream sequence
cattaccattcaggacataggcatgggcaaggacttcatgtctaaaacaccaaaagcaatggcaacaaaagccaaaatggacaaatgggatctaactaaa
Downstream sequence
ctaaagagcttctgcacagcaaaagaaactaccatcagagtgaacaggcaacctacaaaatgggagaaaattttcgcaacctactcatctgacaaagggc
Target sequence
caaaatggacaaatgggatctaactaaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate