Basic Information
VIS ID
TVIS30016570
Fusion event
HIV-EIF2AP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
150181551/150484463 (Hg38)
End
150181483/150484463 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
EIF2AP1
Nearest miRNA
hsa-mir-10399/Upstream/3106342; hsa-mir-153-2/Downstream/753958;
Nearest TSS
ENST00000635602/Upstream/33833; ENST00000313543/Downstream/30367;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/76021, chr7-CpG: 44/Downstream/235863
Nearby gene
GIMAP8(No orient, 5068)
Upstream sequence
CCCTCCTCATGTAGCTTAAGATCAATGACTTGTTCATTTCTTCTAAGTGGAGTTCTAAAAGTCATTGCAATATTGGCTCCTCACAGGGTACTTAGAACTG
Downstream sequence
CTTAATAAGTTATTGATTTTATTGGAAATACTATGTCCAGAATTTTTCGCTAACGATTTCTGCATTTGATGGCATGATATTTTTGTGCAGGATAGAGCTA
Target sequence
TTCATTTCTTCTAAGTGGAGTTCTAAAAGTCATTGCAATATTGGCTCCTCACAGGGTACTTAGAACTG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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