Basic Information
VIS ID
TVIS30016577
Fusion event
HIV-GIMAP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
150429661/150732573 (Hg38)
End
150429564/150732573 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
GIMAP1
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-3689f ; hsa-mir-3689e ; hsa-mir-3689b-5p ; hsa-mir-3689a-5p ; hsa-mir-4494 ; hsa-mir-892a ; hsa-mir-548c-3p ; hsa-mir-4517
Nearest miRNA
hsa-mir-10399/Upstream/3354452; hsa-mir-153-2/Downstream/505848;
Nearest TSS
ENST00000635602/Upstream/10320; ENST00000469272/Downstream/4775;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/11643, chr7-CpG: 124/Downstream/67148
Upstream sequence
CCCCAAGAAGCCTGGGCCAGTCCTACAGATGTGCCTGTTGGTAACTCTGATACCCCATGAtgtcaaatgtcaatagtaatttcagacagaaggaaagcaa
Downstream sequence
gacccagacagcaGGACTTTGTATATTATATTTTTTTCATCAAAAGTagagcttcccaactttttcatgtcgatgtccacatggtaacatttgtcacaac
Target sequence
CAAGAAGCCTGGGCCAGTCCTACAGATGTGCCTGTTGGTAACTCTGATACCCCATGAtgtcaaatgtcaatagtaatttcagacagaaggaaagcaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate