Basic Information
VIS ID
TVIS30016579
Fusion event
HIV-KMT2C integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
152103525/152406440 (Hg38)
End
152103439/152406440 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
KMT2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-940 ; hsa-mir-708-5p ; hsa-mir-106b-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-mir-610 ; hsa-mir-93-3p ; hsa-mir-4663 ; hsa-mir-4632-3p ; hsa-mir-6746-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-934
Nearest miRNA
hsa-mir-10399/Upstream/972801; hsa-mir-153-2/Downstream/5167896;
Nearest TSS
ENST00000635602/Upstream/94144; ENST00000564834/Downstream/29359;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/39445, chr7-CpG: 219/Downstream/28692
Nearest cancer related gene
KMT2C(TSG, No orient, 0)
Upstream sequence
gaggctgaggtaggagaatcatctgattctgggaagtccagggtgcaatgagccatgatcacaccactgtactcccgcctgagagacagagtgagaacct
Downstream sequence
gtctcaaaaaaaaaaaaGGCATCAAAAATGGCTAAAAGAAAATCTTAAACAAACCATGAGTTAACAGATTAAAAAGGTGttcttgtttgttttttgagac
Target sequence
agaatcatctgattctgggaagtccagggtgcaatgagccatgatcacaccactgtactcccgcctgagagacagagtgagaacct
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate