Basic Information
VIS ID
TVIS30016581
Fusion event
HIV-PRAG1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
GRCh37/hg19
Start
8196288/8338772 (Hg38)
End
8196241/8338772 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRAG1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1207-5p ; hsa-mir-1910-3p ; hsa-mir-2682-5p ; hsa-mir-3179 ; hsa-mir-3202 ; hsa-mir-34b-5p ; hsa-mir-4423-3p ; hsa-mir-449c-5p ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4688 ; hsa-mir-4747-5p ; hsa-mir-4763-3p ; hsa-mir-486-3p ; hsa-mir-5196-5p ; hsa-mir-5681a ; hsa-mir-6511a-5p ; hsa-mir-6743-5p ; hsa-mir-6797-5p ; hsa-mir-6808-5p ; hsa-mir-6879-5p ; hsa-mir-6893-5p ; hsa-mir-885-3p ; hsa-mir-940 ; hsa-mir-9500
Nearest miRNA
hsa-mir-3674/Upstream/249683; hsa-mir-10400/Downstream/709673;
Nearest TSS
ENST00000518652/Upstream/112158; ENST00000524073/Downstream/42975;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/19513, chr8-CpG: 88/Downstream/47277
Upstream sequence
TGTTTAGGTAGAATAATGTTGCTGACAGTAAATTTGCAATGGAACCCTCTACTGTGTCATTGCCTATTGAGAAGAAATATTTCCATAGGACTGAAAAAGG
Downstream sequence
AAGTCATGTGAGTACAAGTCTAAATCCAACATGCTAACGCAAGTCTAAGAGAAACGCAGGAGAGGACACATACACAAAGAATGCTGAAAGGGTGAGAGGT
Target sequence
GTGTCATTGCCTATTGAGAAGAAATATTTCCATAGGACTGAAAAAGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate