Basic Information
VIS ID
TVIS30016582
Fusion event
HIV-PCM1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p22
Reference genome
GRCh37/hg19
Start
17802161/17944652 (Hg38)
End
17802255/17944652 (Hg38)
Orient
+
Location type
Intronic
Target gene
PCM1
miRNAs that regulate target gene
hsa-mir-33a-5p ; hsa-mir-129-5p ; hsa-mir-8055
Nearest miRNA
hsa-mir-124-1/Upstream/262995; hsa-mir-10400/Downstream/4300314;
Nearest TSS
ENST00000518652/Upstream/7476; ENST00000517836/Downstream/13006;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/20889, chr8-CpG: 103/Downstream/139138
Upstream sequence
AACTAAAAATATAGTTGGTGAAAGTGACTTTTTCAAAAAAAGTTTAAAGAAAAATATGTGTTTGAAGAATTAATATACACCTAGCATCCTTTTTGGATTT
Downstream sequence
ATCTTTTGGCTCAGTTTTTTTGAGCATCAGTCTGAAATGTTGTTTATATGAATGTGAAAGTTATTAAGTAGTAATATTTCACTAATTTTGAAAATTGAGA
Target sequence
CTATTCCAGGTGCCATCTTCCTGGTATGTTATTACTCCTACCTAGATATTTTTATTTTCTCCCTTCTGTATATTTCATCATAGGCTGTACTCCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate