Basic Information
VIS ID
TVIS30016585
Fusion event
HIV-PPP3CC integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
22361652/22504139 (Hg38)
End
22361596/22504139 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPP3CC
miRNAs that regulate target gene
hsa-mir-6086 ; hsa-mir-6851-3p ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-6832-3p ; hsa-mir-3922-5p
Nearest miRNA
hsa-mir-124-1/Upstream/259102; hsa-mir-10400/Downstream/2449657;
Nearest TSS
ENST00000518652/Upstream/6140; ENST00000523620/Downstream/6769;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/62510, chr8-CpG: 107/Downstream/47020
Nearest cancer related gene
PPP3CC(TSG, No orient, 0)
Upstream sequence
TTTTTAAGAGGGAGGTGGGTGAAGGCTTTTCTTGTATCAATCTTAAATTGCTTTATAATGCAGAGATTTTTTAAAAAATATTCCTTTCTTTATGGAAAAG
Downstream sequence
TAATAATGtttttttttaaattgatgtataatagttgtacgtatttttgaggtacatgtgatatttttactatatgtatacaatgtataattattatcaa
Target sequence
AAATTGCTTTATAATGCAGAGATTTTTTAAAAAATATTCCTTTCTTTATGGAAAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate