Basic Information
VIS ID
TVIS30016588
Fusion event
HIV-LEPROTL1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
29977903/30120387 (Hg38)
End
29977975/30120387 (Hg38)
Orient
+
Location type
Intronic
Target gene
LEPROTL1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-375 ; hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-mir-15a-3p ; hsa-mir-149-5p ; hsa-mir-100-3p ; hsa-mir-595 ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-4423-5p ; hsa-mir-656-5p ; hsa-mir-1255b-2-3p ; hsa-mir-496 ; hsa-mir-3670 ; hsa-mir-6854-5p ; hsa-mir-4538 ; hsa-mir-4453 ; hsa-mir-6727-5p ; hsa-mir-7977 ; hsa-mir-4508 ; hsa-mir-6775-5p ; hsa-mir-5090 ; hsa-mir-383-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6816-5p ; hsa-mir-3196 ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-520h ; hsa-mir-520g-3p
Nearest miRNA
hsa-mir-124-1/Upstream/163039; hsa-mir-10400/Downstream/11150661;
Nearest TSS
ENST00000518652/Upstream/18447; ENST00000522540/Downstream/24299;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/24319, chr8-CpG: 48/Downstream/35797
Upstream sequence
CATAAAAGAACAGCATGGATCCAGATCTCCCCCAGCCATTTGGGGAGAAATAGAAGAATAAGAACTATCATAAGACTGCATGTGCATAAGATGTTACATG
Downstream sequence
tatgcatatatatatatgtatatAtttttttaactctggtaacaaaatacataacatgaaatctaccatcttTGTTTAAttttgtttctgagatgggttc
Target sequence
ATACTCTTTTAGTTGTAAAATATAAAGAGGGCAAAATGTAAATGGTCGCTTAATAAGTTGtatgtatttgta
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate