Basic Information
VIS ID
TVIS30016590
Fusion event
HIV-NSD3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
38173023/38315505 (Hg38)
End
38173139/38315505 (Hg38)
Orient
+
Location type
Exonic
Target gene
NSD3
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-196b-5p ; hsa-mir-301a-3p ; hsa-mir-10b-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-203a-3p ; hsa-mir-526b-5p ; hsa-mir-4635
Nearest miRNA
hsa-mir-124-1/Upstream/8358157; hsa-mir-10400/Downstream/2955543;
Nearest TSS
ENST00000518652/Upstream/15711; ENST00000527912/Downstream/3786;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/45991, chr8-CpG: 160/Downstream/66166
Nearest cancer related gene
NSD3(TSG, No orient, 0)
Upstream sequence
ACCTGCCTACCTGACATACAGTGTCCTTCTTACTCATTCCAGTGCCTCTTCTCGACAAACTTGAATCCATGGACTGCACATCAGAAACGTCTGCATCTGC
Downstream sequence
TAAGACTTGCTCAAACATTAGATCTTGACACAACCACCTTTTTCCTTCCTTTCTTTCCAAAATCCACAGATATCATAGGTCTGCTGTTTTGGGAAAAACT
Target sequence
AGTAGCTGAAGGGCTATCTACTTGCTTTCCAAAGCCTACCTACATAGAAAACATAGCATTTTTAAGAAAAACAAAATGAAAATTCCCTCCAAGATAAGATGCTATGAAAATCCTAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate