Basic Information
VIS ID
TVIS30016592
Fusion event
HIV-TOX integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
60017181/59104622 (Hg38)
End
60017499/59104622 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOX
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-223-3p
Nearest miRNA
hsa-mir-124-1/Upstream/16208347; hsa-mir-10400/Downstream/2610166;
Nearest TSS
ENST00000518652/Upstream/444778; ENST00000523683/Downstream/14418;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/444655, chr8-CpG: 175/Downstream/12953
Upstream sequence
cagaactctgtcactcatgtatttccagttttgctcagatgaagagcaagaggccaatttaaatgttgaattatagcttaatatgtaggtcAAGAAGTAT
Downstream sequence
ttattagccatatggagggagggttcacgacttattcatctctgtgtcccTCCCTGACCCCCTTAACACTTAAAGTTCTGCACTCTGTGTTCAAAAAATG
Target sequence
GCTTGCATCTCCACTTCCGGGAGATAACGTTCTATGTTAATTCAAATAGCCCTATTGTATGTGTGGCTTTTATTTTGAGTTATCATAGATCATTTTATAAAAGGTGAGAAGTCTAAAAAATAATTCAAAAAATTAggagtaactttccccttcttcactgctggatttttgaggccaattgaaatgccatctcctccaggaagcaacagggattcctccaacttcaacttttccttttatactgccagcactttg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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