Basic Information
VIS ID
TVIS30016594
Fusion event
HIV-CHD7 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
61594573/60682014 (Hg38)
End
61594472/60682014 (Hg38)
Orient
-
Location type
Intronic
Target gene
CHD7
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-mir-877-3p ; hsa-mir-454-3p ; hsa-mir-615-3p ; hsa-let-7e-5p ; hsa-let-7b-5p ; hsa-mir-155-5p ; hsa-mir-219a-5p ; hsa-mir-759 ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-4683 ; hsa-mir-5186 ; hsa-mir-544a ; hsa-mir-6857-5p ; hsa-mir-4450 ; hsa-mir-5187-5p ; hsa-mir-5589-5p ; hsa-mir-5189-3p ; hsa-mir-4731-5p ; hsa-mir-8089 ; hsa-mir-4700-5p ; hsa-mir-4667-5p ; hsa-mir-3692-5p ; hsa-mir-1322 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-1246
Nearest miRNA
hsa-mir-124-1/Upstream/17785739; hsa-mir-10400/Downstream/1032774;
Nearest TSS
ENST00000518652/Upstream/2450; ENST00000527825/Downstream/59351;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1393, chr8-CpG: 39/Downstream/32107
Upstream sequence
TATATGAATTTTAAATTATTATATTCATTTAATCAATGGCCTTATTTTTAAATTAGTTTTTTTAAAAAGTTACTTTCTTTTATATGTCTTAACATGGAAG
Downstream sequence
GCACAATACAGGAATGGTAGAGTGGTTGTACCGGTGATGTTTAAAAACCCAAATATTATTTTCCTCTTTCAAGGAAAGAAATAACTTTTTTTCCCAAGTT
Target sequence
GTATATGAATTTTAAATTATTATATTCATTTAATCAATGGCCTTATTTTTAAATTAGTTTTTTTAAAAAGTTACTTTCTTTTATATGTCTTAACATGGAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate