Basic Information
VIS ID
TVIS30016597
Fusion event
HIV-PDE7A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
66636827/65724592 (Hg38)
End
66636962/65724592 (Hg38)
Orient
+
Location type
Intronic
Target gene
PDE7A
miRNAs that regulate target gene
hsa-mir-409-3p ; hsa-mir-6807-5p ; hsa-mir-210-5p ; hsa-mir-203a-3p ; hsa-mir-345-3p ; hsa-mir-640 ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-7977 ; hsa-mir-383-3p ; hsa-mir-6871-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-1-5p ; hsa-mir-221-5p ; hsa-mir-3672 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4461 ; hsa-mir-4767 ; hsa-mir-4768-3p ; hsa-mir-4786-5p ; hsa-mir-4793-5p ; hsa-mir-5186 ; hsa-mir-6087 ; hsa-mir-6089 ; hsa-mir-6502-3p ; hsa-mir-6864-3p ; hsa-mir-6888-5p ; hsa-mir-769-5p ; hsa-mir-8073
Nearest miRNA
hsa-mir-124-1/Upstream/1345335; hsa-mir-10400/Downstream/8823951;
Nearest TSS
ENST00000518652/Upstream/9814; ENST00000527553/Downstream/759;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/79314, chr8-CpG: 128/Downstream/116762
Upstream sequence
ATTTATGAGAATAAAATGCTATTTCTTAATTGGTACCCTAATCTTGTAAAAATTGTTTTCATCAGAAATCTTGAGTATGAAAAACACGTAAGCAATGATG
Downstream sequence
AGTCACATAATTTATCCTAGAAATAGAATGTTTCCAAGCCCCATTTTACCTGTAAAACCAAATGTCTGTGTCTGGTGTCTTCTAGGCATAAATCACCTCT
Target sequence
CCTTCCTAGGTAGCAGATTCACCAGTGATCTCCTTTTGGAAGGAGTGTGCGCTAATTGAAGGAAATTCTTTAGCTTGCCCTCAAGATTTAACCATTCTGAAAAACTACACTAGAATATTCATTTTTTAGTTTGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate