Basic Information
VIS ID
TVIS30016600
Fusion event
HIV-NCOA2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
71211716/70299481 (Hg38)
End
71211746/70299481 (Hg38)
Orient
+
Location type
Intronic
Target gene
NCOA2
miRNAs that regulate target gene
hsa-mir-137 ; hsa-mir-193b-3p ; hsa-mir-544a ; hsa-mir-1185-5p ; hsa-mir-6864-5p ; hsa-mir-4471 ; hsa-mir-8059 ; hsa-mir-539-5p ; hsa-mir-3179 ; hsa-mir-7515 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-3120-3p ; hsa-mir-429 ; hsa-mir-200b-3p ; hsa-mir-200c-3p
Nearest miRNA
hsa-mir-124-1/Upstream/5920224; hsa-mir-10400/Downstream/4249062;
Nearest TSS
ENST00000518652/Upstream/54106; ENST00000520259/Downstream/102598;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/226828, chr8-CpG: 251/Downstream/102429
Upstream sequence
TAATTATCTGATAAAGGACACATATCTAGAATATATTATATAAGGAGCTAAATtatttgataaagggcatgtatctagaatatataaagatctcttacaa
Downstream sequence
tttaaatgggcaacatattctgcaactcaccatgagatatacaataaggaaaagtacatgaaaaaatactcaacatcattagttattaggaaaatggaaa
Target sequence
cttaataataggacaaataattcaattatt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate