Basic Information
VIS ID
TVIS30016604
Fusion event
HIV-INTS8 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
95842756/94830528 (Hg38)
End
95842632/94830528 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
INTS8
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-132-3p ; hsa-mir-128-3p ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-340-5p ; hsa-mir-3163 ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p
Nearest miRNA
hsa-mir-12123/Upstream/914409; hsa-mir-10400/Downstream/242383;
Nearest TSS
ENST00000518652/Upstream/1536; ENST00000520853/Downstream/23266;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/6824, chr8-CpG: 209/Downstream/64032
Nearest cancer related gene
INTS8(OG, No orient, 0)
Upstream sequence
ctagttcctaataaaatgactggcacattgaagtatacagatatttcttgaataaatcaaGTGGAACAGTGCAAAttttttcttttttagacagggtctg
Downstream sequence
actctgttgcccaggctacagtgcagtggcctgatcttggctcattgcagcctccacctcccagcctcaagcgatcctcccacctcagtgttgccagtag
Target sequence
CCTACATCATttcattgttgttatctagttcctaataaaatgactggcacattgaagtatacagatatttcttgaataaatcaaGTGGAACAGTGCAAAttttttcttttttagacagggtctg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate