Basic Information
VIS ID
TVIS30016605
Fusion event
HIV-STK3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
99748934/98736706 (Hg38)
End
99749006/98736706 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
STK3
miRNAs that regulate target gene
hsa-mir-141-3p ; hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-133b
Nearest miRNA
hsa-mir-12123/Upstream/342968; hsa-mir-10400/Downstream/799930;
Nearest TSS
ENST00000518652/Upstream/84982; ENST00000606778/Downstream/88940;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/308509, chr8-CpG: 90/Downstream/88527
Upstream sequence
TCAAAAATAGACAATAGTCAATAATTCAGAATCAAGAACGCTTTACCCCTAATAAGATTTCTTTCAAAGACAAGCACAATTCCACACACAAAATAAATAT
Downstream sequence
CTAAATCATCACATAATTTTGTTTCTTCTCTATAATAAATGAAGCTCACTATATATAAATATGTACAAATAGAATATGCAAATTATACATAGACAATATC
Target sequence
GTTACTTAGGTGGTTCTCCAAGACTTACTACTCTTAAAACAAATTAAAAATTTAGAATCTATTGTCAACTCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate