Basic Information
VIS ID
TVIS30016607
Fusion event
HIV-UBR5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
103397214/102384986 (Hg38)
End
103397272/102384986 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
UBR5
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-1-3p ; hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-331-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-20b-5p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-12123/Upstream/259471; hsa-mir-10400/Downstream/769628;
Nearest TSS
ENST00000518652/Upstream/23777; ENST00000523572/Downstream/27703;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/145138, chr8-CpG: 122/Downstream/26831
Upstream sequence
TCAAGAGCTTTAATCTGAAATACCAACAAAGGGTTACTGAGTCCCTCAACACATACCAAAAAATAATTTGAAACAGAAATTCATTTGAATGATGGCAAGG
Downstream sequence
GCCTAGTACAAAATGTTAGCTGCTCCTGCTGTTTCTTCCATCACCATTTCTGACTGAAAGAAAAACTGTTAAATGAGACGCGTAAAAAGGAATTTGGGGA
Target sequence
TTTACTTAAGACATTGGCATCAACAGGGTATTACAGCACATAATATGCTTAGTACAGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate