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TVIS30016608
Basic Information
VIS ID
TVIS30016608
Fusion event
HIV-LRP12 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
105558404/104546176 (Hg38)
End
105558346/104546176 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
LRP12
miRNAs that regulate target gene
hsa-mir-615-3p
;
hsa-mir-5011-5p
;
hsa-mir-5093
;
hsa-mir-3688-3p
;
hsa-mir-4473
;
hsa-mir-633
;
hsa-mir-636
;
hsa-mir-512-3p
;
hsa-mir-548p
;
hsa-mir-5692a
;
hsa-mir-4796-3p
;
hsa-mir-548ah-5p
;
hsa-mir-3609
;
hsa-mir-20b-5p
;
hsa-mir-20a-5p
;
hsa-mir-106a-5p
;
hsa-mir-106b-5p
;
hsa-mir-519d-3p
;
hsa-mir-526b-3p
;
hsa-mir-93-5p
;
hsa-mir-17-5p
;
hsa-mir-520f-3p
;
hsa-mir-302c-3p
Nearest miRNA
hsa-mir-12123/Upstream/61711; hsa-mir-10400/Downstream/8097317;
Nearest TSS
ENST00000518652/Upstream/48571;
ENST00000521923/Downstream/42819;
Nearest CpG islands
None/Target,
chr8-CpG: 109/Upstream/79064
,
chr8-CpG: 115/Downstream/42049
Upstream sequence
CAGTGGGCAAGATCTTTCACACTGTGGGGCTTGTAACTGGGGCTCAGAGGGGACAGTAAGAGACTAGCGATAAAAATGTTAGAAACCTTTGGTATCAACT
Downstream sequence
CTATTTTATTAACAGTTGATGTAACTGGAGTACACAGAAAAGGGAAAGGCAGTTATCtttataaaatcagctttgttgaggtataacttatatgcaaaaa
Target sequence
CTCAGAGGGGACAGTAAGAGACTAGCGATAAAAATGTTAGAAACCTTTGGTATCAACT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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