Basic Information
VIS ID
TVIS30016611
Fusion event
HIV-FBXO32 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
124547911/123535671 (Hg38)
End
124548125/123535671 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
FBXO32
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-608 ; hsa-mir-593-5p ; hsa-mir-541-5p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426
Nearest miRNA
hsa-mir-12123/Upstream/187541; hsa-mir-10400/Downstream/972844;
Nearest TSS
ENST00000518652/Upstream/3528; ENST00000518633/Downstream/5518;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/118486, chr8-CpG: 145/Downstream/4628
Nearby gene
FBXO32(No orient, 3528)
Nearest cancer related gene
FBXO32(TSG, No orient, 0)
Upstream sequence
ACAGGTCACTGAAGGATGGGCAGGCTCATCTCGGGCCAGACGCTTATTTGCCTCAGTGGGCTGAGCAATCATTTGAGGGGTAATGAACTATTCTACTATA
Downstream sequence
CTGCTGAATTTAAAATGTAACTTGATTTACATCTTTTTCAGATATACATCTGTTGGGTACAATTATGTACATCTGCACTTCTCTATTTCCTTGGCATTGT
Target sequence
CAATGTAACTTCAAAGTAAATCTCTGAATAATTTCCACAGAAGGAATGCAGGAGAAATACTGAGGTATGATAAGATAGGTTCCCTAACTCCCTCAACCCCCACAAAGTATGTAAAACAGGATTTATAATGCCAACTGGTAAAACATAAATTAGGGGTTTTTTTTTTTTTGCTATACCACCGATATTTTATACTCCTTTAATGTTCTGAGTTTCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate