Basic Information
VIS ID
TVIS30016614
Fusion event
HIV-SQLE integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
126012090/124999848 (Hg38)
End
126012261/124999848 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
SQLE
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-let-7e-5p ; hsa-mir-205-5p
Nearest miRNA
hsa-mir-12123/Upstream/177790; hsa-mir-10400/Downstream/2796114;
Nearest TSS
ENST00000518652/Upstream/1304; ENST00000520493/Downstream/9432;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/896, chr8-CpG: 39/Downstream/91670
Upstream sequence
TTCACTCAAATATAAGTTTTATTTGAATTGCAAAAGGCGGCAGGTTAGATGCTTGTATACATTCTCATGTATTTTTTATTTTAAACTCTGCTGTGCCTTG
Downstream sequence
TTCTTGGGTAAGGATTGGATTTGTGCCTGAGGAAGAAAGAAACGTGCTGCGGGTAAGTCCACTGCTTGTAAGAAGTGACAGCTGACTGGGGAAAGTGACA
Target sequence
GTTACATCTTTGACCTTCTTAAGAATGAGTGAAGACATTTGTTTCATTTAGCATTGGTTGAGCCTCAGATGGAGGTTGGATATTTGATTATGAAAGATGGAACGAAATGTTAGAATTTCATTTTGAAGGAGAAGAACAACCACTTTCCATGATGAAAAAGTTTTTAAAAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate