Basic Information
VIS ID
TVIS30016619
Fusion event
HIV-TRAPPC9 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
141386021/140375922 (Hg38)
End
141385802/140375922 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
TRAPPC9
miRNAs that regulate target gene
hsa-mir-30e-5p ; hsa-mir-196a-5p ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-6873-5p ; hsa-mir-583
Nearest miRNA
hsa-mir-1204/Upstream/5570977; hsa-mir-10400/Downstream/356642;
Nearest TSS
ENST00000518652/Upstream/73087; ENST00000518971/Downstream/59275;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/26400, chr8-CpG: 78/Downstream/81197
Upstream sequence
AAGTCAGTGACAGATGTGTAGGGGCAGCCTGGTGGCCGCACTCAACTAAATGATGACCGTGGGAGAATGCCGGATGGGAAACAGCAGGCCCCACACATTC
Downstream sequence
CCAGGTTTGAAAACACACTCTGCTCCTCTCTCCGGCTATTTCCAGCCATAATTACATGGAGAGAAAATACATCTTCAAAATTATACAAACTTTCCATATA
Target sequence
GTTAATGCCTTTGACACCACAAGTTCTAACCCCAAGTTAACCAGCCACTGATGCTCTAGAAAATGCCTTAACCCTCATCAGCCTTCTCAAACGTGGGCACTTGCAGTGATCAGAAGAACAAGTCAGTGACAGATGTGTAGGGGCAGCCTGGTGGCCGCACTCAACTAAATGATGACCGTGGGAGAATGCCGGATGGGAAACAGCAGGCCCCACACATTC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate