Basic Information
VIS ID
TVIS30016621
Fusion event
HIV-MROH1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145264509/144209606 (Hg38)
End
145264578/144209606 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
MROH1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-222-3p ; hsa-mir-1273h-3p ; hsa-mir-3166 ; hsa-mir-3929 ; hsa-mir-4251 ; hsa-mir-4419b ; hsa-mir-4478 ; hsa-mir-4768-3p ; hsa-mir-4771 ; hsa-mir-485-5p ; hsa-mir-6884-5p
Nearest miRNA
hsa-mir-1204/Upstream/129664; hsa-mir-10400/Downstream/53067;
Nearest TSS
ENST00000518652/Upstream/10487; ENST00000528664/Downstream/29506;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/6232, chr8-CpG: 19/Downstream/29041
Upstream sequence
aggcagagcttgcagtgagctgagatggtgccactgcactccagcctgggcgacagagtgagactccgtctcaaaaaaaaaaaaagaaaaaagaaaaaTC
Downstream sequence
tagcaagcagatcgctttatcctaggagcttcagactaggctgaaaaacatggtgaaaccctgtctctactaaaaataaaaaaagccaggtgtggtagca
Target sequence
GTTAGTATAAAAGAAATCATGGAAgggcacagtggctcacacctgtaatcctagcactttgggatcccg
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate