Basic Information
VIS ID
TVIS30016626
Fusion event
HIV-LRRC14 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145746371/144520987 (Hg38)
End
145746423/144520987 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA8D
Target gene
LRRC14
Nearest miRNA
hsa-mir-10400/Upstream/58448; hsa-mir-6850/Downstream/270944;
Nearest TSS
ENST00000518652/Upstream/1720; ENST00000530242/Downstream/1595;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/342, chr8-CpG: 126/Downstream/1138
Upstream sequence
TGTGACCCCTGTGTCCCCTGTAGCACCCTGCAGAGCCCCCTGGAGAGCCTGGAGTTGGCCTTCTGTGCTCTGCTGCCTGAGGACCTACGCTTCCTGGCAC
Downstream sequence
GTCTGGCAGCCAGCTGGCACCCTTCCAGGGTCTGTTGCAGGCATCAGCAGCCACACTGTTGCATCTGGAGCTGACTGAGTGTCAGCTCGCAGACACCCAG
Target sequence
GGAGCCCACATGCTGCCCACCTCAAGAAGTTGGACCTGAGTGGTAACGACCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate