Basic Information
VIS ID
TVIS30016628
Fusion event
HIV-LRRC14 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145746808/144521424 (Hg38)
End
145746915/144521424 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA8D
Target gene
LRRC14
Nearest miRNA
hsa-mir-10400/Upstream/58885; hsa-mir-6850/Downstream/270507;
Nearest TSS
ENST00000518652/Upstream/2157; ENST00000530242/Downstream/1158;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/779, chr8-CpG: 126/Downstream/701
Upstream sequence
TGCCTCTGTCCTGCTGGAGGCCTCCATCAATGAGGAGAAGTTTGCCCGCGTAGAAGCTGAGTTGCACCAGCTGCTTCTAGCCTCAGGCCGTGCCCATGTG
Downstream sequence
GGGCCTTTGCTGGGACCCCTGGTGGAGGCCTTCACAAAAGCACTGGTTACTGGTTTCCTGCTGGGTCTACCTTGCTTCTGGGCACACCTCAAGCCTCCCC
Target sequence
CTCTGGACCACGGACATCTACGGGCGACTGGCTGCGGACTACTTCAGCCTATGATGAAGTAGCTCTGGGTGAGACACAGGCCGCCCTGCAGTCTCTTTAGGTAGGCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate