Basic Information
VIS ID
TVIS30016629
Fusion event
HIV-chr8 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145989631/144764246 (Hg38)
End
145989801/144764246 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA8D
Nearest miRNA
hsa-mir-10400/Upstream/301707; hsa-mir-6850/Downstream/27685;
Nearest TSS
ENST00000518652/Upstream/7829; ENST00000528012/Downstream/16036;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/8397, chr8-CpG: 81/Downstream/22559
Nearby gene
ZNF251(No orient, 8661)
Upstream sequence
gagccgagatcacaccactgcactccagctacagagtgagagtctgtctaaaaaaaaaaattccaatagaaaaaaaTGGGCAAAAACAGGGACAAAGTTG
Downstream sequence
TTGTGGGTTCATGAGGGGACGCACGCAAGGGATGTCCCAGCAATGAGAACATGGAATGACCTGAATGAGAGCGGGGGAGGGGCCACCCGGGACAAAGCTG
Target sequence
AAAAGCACATGGCCAAGAAACACCCGACAGTAACAAATGCACAGATGTGGGGAACTGGTGCGAGTCTTCAGAGCTGGCGGAAATGGGAAGCGGAGTAACTATTTTGGCAGAAAAATACGTAACTTCCCTGCGAACCGGAATCCCACGTGTACACATCCAGAGAGTTCCCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate