Basic Information
VIS ID
TVIS30016634
Fusion event
HIV-JAK2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
5029630/5029630 (Hg38)
End
5029748/5029630 (Hg38)
Orient
+
Location type
Intronic
Target gene
JAK2
miRNAs that regulate target gene
hsa-mir-135a-5p ; hsa-mir-375 ; hsa-mir-335-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-101-3p ; hsa-mir-8485 ; hsa-mir-548as-3p ; hsa-mir-568 ; hsa-mir-5692a ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-216a-5p ; hsa-mir-204-5p
Nearest miRNA
hsa-mir-101-2/Upstream/179255; hsa-let-7a-1/Downstream/978196;
Nearest TSS
ENST00000422679/Upstream/44385; ENST00000519308/Downstream/83919;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/44000, chr9-CpG: 85/Downstream/11104
Nearest cancer related gene
JAK2(OG, No orient, 0)
Upstream sequence
aaagaaaaaaaccccacaatatctgcaaagtacaataatgcagggtgcactaaaatgaagtatgtttgTATAAAAAAAGATTGTGATTAATAATTCAGTT
Downstream sequence
CCTTTAATAATTCCTTTCTCTGCTTCTTTTCTAGGTATCACACCTGTGTATCATAATATGTTTGCTTTAATGAGTGAAACAGAAAGGATCTGGTATCCAC
Target sequence
GTAGGGGTTGGTATATCAAAAGATTTCGACTGCTATTACATTTTGTTCCGATTTTAAGAGTTGTTACTTTAGCTTCATTTCAAATTATAGGTGCTATGTAAAAATATTCTGTTGTGTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate