Basic Information
VIS ID
TVIS30016645
Fusion event
HIV-CLTA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
36195215/36195218 (Hg38)
End
36195241/36195218 (Hg38)
Orient
+
Location type
Intronic
Target gene
CLTA
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-23b-3p ; hsa-mir-142-3p ; hsa-mir-3159 ; hsa-mir-4255 ; hsa-mir-3678-3p ; hsa-mir-4662a-3p ; hsa-mir-6073 ; hsa-mir-6869-5p ; hsa-mir-1273h-3p ; hsa-mir-7852-3p ; hsa-mir-33a-3p ; hsa-mir-653-3p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-6837-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-101-2/Upstream/462223; hsa-let-7a-1/Downstream/628321;
Nearest TSS
ENST00000422679/Upstream/4053; ENST00000489766/Downstream/54178;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/3679, chr9-CpG: 76/Downstream/62955
Upstream sequence
tttaaaactatctcactcttctgtcttacacaaaaataaattccaggtggattaaagaGAGACATTTAAAAAGTAAAAGAAGAAAAGTGAGTATTTGTCT
Downstream sequence
ATAAAAGCAGATACAGAAATCATGAAGAAAAAGTCGATCATGTCTACATACACAAATTAAGTTGTTCCAAGTGTTAAATACCATAAACCAAATCAAAAGA
Target sequence
ATCTCATAATAGGAAAGGCCTTCAGC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate