Basic Information
VIS ID
TVIS30016651
Fusion event
HIV-PCSK5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
78746298/76131382 (Hg38)
End
78746234/76131382 (Hg38)
Orient
-
Location type
Intronic
Target gene
PCSK5
miRNAs that regulate target gene
hsa-mir-107
Nearest miRNA
hsa-mir-101-2/Upstream/5321298; hsa-let-7a-1/Downstream/7838366;
Nearest TSS
ENST00000422679/Upstream/35405; ENST00000455778/Downstream/57257;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/238646, chr9-CpG: 101/Downstream/262339
Upstream sequence
TCCAGCAAAATTAACCTATGGCTATTTCCTGAGCTAATTATCTTCCCACAGATAGAAACACTACTGATTCCAGGTCCACTGGTTTTTCAATTTATCTTCT
Downstream sequence
TTACTTTATTTTGGTGAAATTCAGGAAATTTTCAAATTAGATCATTTCTGAAGTTGTGCATTACCAAATATCAGAGTAAAACCATCCAAACACCTTCTTT
Target sequence
ATTATCTTCCCACAGATAGAAACACTACTGATTCCAGGTCCACTGGTTTTTCAATTTATCTTCT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate