Basic Information
VIS ID
TVIS30016654
Fusion event
HIV-AUH integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
94025834/91263552 (Hg38)
End
94025990/91263552 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9D
Target gene
AUH
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-183-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1240017; hsa-let-7a-1/Downstream/372699;
Nearest TSS
ENST00000422679/Upstream/42633; ENST00000442072/Downstream/92569;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/69414, chr9-CpG: 74/Downstream/97959
Upstream sequence
TGAAGAAAAAGTTTTCATATTATTTTATTTAAGGCTAGTATCAAAGAGTTCAGACAATTATTTAAACTAACTCTTTAACAAAACTTCATTATAGGTCTAG
Downstream sequence
gtatttcattcttctggtagtcatctctatatccctaaatagtaaacttgtatctaggtttctggatttaataattttacataatgtctactgattctcc
Target sequence
ATTAGTGAAACGCCAAATTAGGAAATATTTTAAGTGTTTTGTTTTCTCAAAATATGTAAATGTAGAATAAATCCAATAACACTAGAGAATTTCTGTTtccacattccctccctataccatgacccattcctcagaataaattttctgactattctt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate