Basic Information
VIS ID
TVIS30016670
Fusion event
HIV-SPTAN1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
131320636/128558357 (Hg38)
End
131320842/128558357 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPTAN1
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-93-3p ; hsa-mir-331-3p ; hsa-mir-128-3p
Nearest miRNA
hsa-let-7a-1/Upstream/165643; hsa-mir-12126/Downstream/1311248;
Nearest TSS
ENST00000422679/Upstream/5025; ENST00000472211/Downstream/8384;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/5140, chr9-CpG: 89/Downstream/98035
Upstream sequence
TTCGCATTACTTGCTGAATGATGCAGCTAACGTTTGACTGCTGCGTTGCAGCATTTATAAATAGCCTACGTCTTCAGTCTCCTCTAATAATATTTTGCAA
Downstream sequence
GTGGAACTGATAGATAGGCTGGTAAGATTGGAGTTTGTTTTTTAATGGCACGTTTCCCAGATTTTTCCTTTCTGGTGCTCTCAAAAGGCGTTAATCCCAT
Target sequence
ATATATACCTTTTTTTTTAAGTTACCTTAAATGGGAAGTTGTCCTTAAACATATAGAGAATATACTTAGCACTTCATTTCCCCTCCTTCAGTCTCTATGTGAACAGACTTGATTGGCAAAATCAGAGACAGTTGGCTCCTTTGAGATAAGCAGTCAGTTGATTGCATTCCTAGGAAGTCGTCTCTGTTGTGGTTTTTAGGCAGTTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate