Basic Information
VIS ID
TVIS30016671
Fusion event
HIV-SPTAN1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
131342244/128579965 (Hg38)
End
131342153/128579965 (Hg38)
Orient
-
Location type
Intronic
Target gene
SPTAN1
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-93-3p ; hsa-mir-331-3p ; hsa-mir-128-3p
Nearest miRNA
hsa-let-7a-1/Upstream/187251; hsa-mir-12126/Downstream/1289640;
Nearest TSS
ENST00000422679/Upstream/13224; ENST00000472211/Downstream/988;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/26748, chr9-CpG: 89/Downstream/76427
Upstream sequence
CTGCAGAGGTTTAAAAAGAAGGTATATGTATAGTGTGCTGATTTCCTGAGAGACAGTCCTCCTTATCTGGGGCATGTGTGGCATGTTTCCTACTTACAGG
Downstream sequence
GACTTTCTGTAGGGAGCTGAGTCTTGCATTAGGAGTTGGAGCAAAGAGGAAACAAATTTTTATAAAATGATACATAGGCCAGGTGTGGtgtgaccccagc
Target sequence
TTTAAAAAGAAGGTATATGTATAGTGTGCTGATTTCCTGAGAGACAGTCCTCCTTATCTGGGGCATGTGTGGCATGTTTCCTACTTACAGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate