Basic Information
VIS ID
TVIS30016688
Fusion event
HIV-RABL6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
139709745/136815293 (Hg38)
End
139709606/136815293 (Hg38)
Orient
-
Location type
Intronic
Target gene
RABL6
miRNAs that regulate target gene
hsa-mir-1226-3p ; hsa-mir-425-5p ; hsa-mir-484 ; hsa-mir-191-5p ; hsa-mir-222-3p ; hsa-mir-10a-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-let-7a-1/Upstream/68323; hsa-mir-3621/Downstream/15664;
Nearest TSS
ENST00000422679/Upstream/6445; ENST00000436380/Downstream/6036;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/6522, chr9-CpG: 86/Downstream/5918
Upstream sequence
CTTGGCTGGGGTGTCCCTTCTTGCCAGGAGCTGCTGCCAGTGCTTTGCCTGCTATGGCTCCCTTCTTGGCAGGTGTGGCGACTGCTTTGCCTGGAGTGAC
Downstream sequence
AGTTGCTTTCTTGGTGGGTGTGGCACCTGCAGCCTTTTTTGTTCGGGAAACTGTCACCTTCTTGGCTGGGGTTGCAGCAGCCTTCTTGCCTTTCTCCTGA
Target sequence
GCTGTCTTCCTTCTTGGCGTTCTTGCCGTTCTTTGCCCCCTTGGCTGGGGTGTCCCTTCTTGCCAGGAGCTGCTGCCAGTGCTTTGCCTGCTATGGCTCCCTTCTTGGCAGGTGTGGCGACTGCTTTGCCTGGAGTGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate