Basic Information
VIS ID
TVIS30016748
Fusion event
HIV-AP1S2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
15858834/15840711 (Hg38)
End
15858940/15840711 (Hg38)
Orient
+
Location type
Intronic
Target gene
AP1S2
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-211-5p ; hsa-mir-2681-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-542-3p ; hsa-mir-4504 ; hsa-mir-6832-3p ; hsa-mir-3938 ; hsa-mir-5580-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/2250365; hsa-let-7f-2/Downstream/786301;
Nearest TSS
ENST00000429181/Upstream/50199; ENST00000380289/Downstream/4805;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/50010, chrX-CpG: 133/Downstream/13381
Upstream sequence
GAAAAACTGGTAAGTGCTTGACTTTACAGAAAAAAAGCCATACTATTATTTCCTTTGTCATTATATATGTGTGTGTTTAAATAAATCCAACTACATCACC
Downstream sequence
TTAATAATTTAAGAATCATCTTTAGTACCAGTGGCATGTTAAGACAGCCAAACATTAAAAAATGGATAACGGGCCAATTTCTGGGCTTTACCCCCAAATC
Target sequence
ACCCCCCACCATATCCCTCCAAAAATCTAGCTTAAAATAGGTGGTGGGGAAAAGTATTCCAAGTATTGCAAAGAATATCAATTTAGCAATTTCAGCATGTTGTACT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate